[HTML][HTML] Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells

G Zhu, D Gao, L Li, Y Yao, Y Wang, M Zhi… - Nature …, 2023 - nature.com
Cultured meat production has emerged as a breakthrough technology for the global food
industry with the potential to reduce challenges associated with environmental sustainability …

[HTML][HTML] Single-cell transcriptomic characterization of sheep conceptus elongation and implantation

GX Jia, WJ Ma, ZB Wu, S Li, XQ Zhang, Z He, SX Wu… - Cell Reports, 2023 - cell.com
Bidirectional communication between the developing conceptus and endometrium is
essential for pregnancy recognition and establishment in ruminants. We dissect the …

Research progress and application prospects of stable porcine pluripotent stem cells

J Zhang, M Zhi, D Gao, Q Zhu, J Gao… - Biology of …, 2022 - academic.oup.com
Pluripotent stem cells (PSCs) harbor the capacity of unlimited self-renewal and multilineage
differentiation potential, which are crucial for basic research and biomedical science …

An optimized culture system for efficient derivation of porcine expanded potential stem cells from preimplantation embryos and by reprogramming somatic cells

D Ruan, Y Xuan, TTKK Tam, ZX Li, X Wang, S Xu… - Nature …, 2024 - nature.com
Pigs share anatomical and physiological traits with humans and can serve as a large-animal
model for translational medicine. Bona fide porcine pluripotent stem cells (PSCs) could …

Super-enhancers conserved within placental mammals maintain stem cell pluripotency

J Zhang, Y Zhou, W Yue, Z Zhu, X Wu… - Proceedings of the …, 2022 - National Acad Sciences
Despite pluripotent stem cells sharing key transcription factors, their maintenance involves
distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can …

[HTML][HTML] Efficient derivation of transgene-free porcine induced pluripotent stem cells enables in vitro modeling of species-specific developmental timing

JV Conrad, S Meyer, PS Ramesh, JA Neira… - Stem Cell Reports, 2023 - cell.com
Sus scrofa domesticus (pig) has served as a superb large mammalian model for biomedical
studies because of its comparable physiology and organ size to humans. The derivation of …

[HTML][HTML] Pig blastocyst-like structure models from embryonic stem cells

J Xiang, H Wang, B Shi, J Li, D Liu, K Wang, Z Wang… - Cell Discovery, 2024 - nature.com
Pluripotent stem cells have the potential to generate embryo models that can recapitulate
developmental processes in vitro. Large animals such as pigs may also benefit from stem …

[HTML][HTML] Spatio-temporal transcriptome dynamics coordinate rapid transition of core crop functions in 'lactating'pigeon

Y Wang, X Wang, Y Luo, J Zhang, Y Lin, J Wu… - PLoS …, 2023 - journals.plos.org
Pigeons (Columba livia) are among a select few avian species that have developed a
specialized reproductive mode wherein the parents produce a 'milk'in their crop to feed …

Generation of stable integration‐free pig induced pluripotent stem cells under chemically defined culture condition

Q Zhu, F Wang, D Gao, J Gao, G Li, D Jiao… - Cell …, 2023 - Wiley Online Library
Genome integration‐free pig induced pluripotent stem cells (iPSCs) bring tremendous value
in pre‐clinical testing of regenerative medicine, as well as conservation and exploitation of …

[HTML][HTML] Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling

VB Alarcon, Y Marikawa - Reproduction, 2022 - rep.bioscientifica.com
In brief Trophectoderm is the first tissue to differentiate in the early mammalian embryo and
is essential for hatching, implantation, and placentation. This review article discusses the …