[HTML][HTML] Amyloidosis in Alzheimer's disease: Pathogeny, etiology, and related therapeutic directions
C Ma, F Hong, S Yang - Molecules, 2022 - mdpi.com
The amyloid hypothesis of Alzheimer's disease has long been the predominant theory,
suggesting that Alzheimer's disease is caused by the accumulation of amyloid beta protein …
suggesting that Alzheimer's disease is caused by the accumulation of amyloid beta protein …
Obesity and neuroinflammation: a pathway to cognitive impairment
AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …
including cognitive dysfunction. In this review we will address the evidence that obesity and …
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer's disease
Inflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Some
evidence suggests that misfolded protein aggregates found in AD brains may have …
evidence suggests that misfolded protein aggregates found in AD brains may have …
[PDF][PDF] Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
MP Mattson - Cell metabolism, 2012 - cell.com
Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …
of limited food sources, and brain function can therefore be optimized by intermittent dietary …
Obesity in aging exacerbates blood–brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes …
Z Tucsek, P Toth, D Sosnowska… - … Series A: Biomedical …, 2014 - academic.oup.com
There is growing evidence that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …
function in the elderly population. However, the specific mechanisms through which aging …
[PDF][PDF] Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
Is Alzheimer's disease risk modifiable?
A Serrano-Pozo, JH Growdon - Journal of Alzheimer's disease, 2019 - content.iospress.com
Population-based clinic-pathological studies have established that the most common
pathological substrate of dementia in community-dwelling elderly people is mixed …
pathological substrate of dementia in community-dwelling elderly people is mixed …
Proteotoxicity and cardiac dysfunction—Alzheimer's disease of the heart?
MS Willis, C Patterson - New England Journal of Medicine, 2013 - Mass Medical Soc
Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? | NEJM Skip to
main content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare …
main content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare …
[HTML][HTML] High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
EM Knight, IVA Martins, S Gümüsgöz, SM Allan… - Neurobiology of …, 2014 - Elsevier
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of A lzheimer's Disease
C Tapia‐Rojas, F Aranguiz, L Varela‐Nallar… - Brain …, 2016 - Wiley Online Library
A lzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory
and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid‐β …
and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid‐β …