MicroRNAs in Alzheimer's disease: function and potential applications as diagnostic biomarkers

W Wei, ZY Wang, LN Ma, TT Zhang, Y Cao… - Frontiers in molecular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. Although the incidence of
AD is high, the rates of diagnosis and treatment are relatively low. Moreover, effective means …

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

N Chopra, R Wang, B Maloney, K Nho, JS Beck… - Molecular …, 2021 - nature.com
Alzheimer's disease (AD) is the most common age-related form of dementia, associated with
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …

Internal ribosome entry site (IRES)-mediated translation and its potential for novel mRNA-based therapy development

R Marques, R Lacerda, L Romão - Biomedicines, 2022 - mdpi.com
Many conditions can benefit from RNA-based therapies, namely, those targeting internal
ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors …

The amyloid precursor protein: A converging point in Alzheimer's disease

A Delport, R Hewer - Molecular Neurobiology, 2022 - Springer
The decades of evidence that showcase the role of amyloid precursor protein (APP), and its
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …

Potential implications of miRNAs in the pathogenesis, diagnosis, and therapeutics of Alzheimer's disease

L Wang, X Shui, Y Diao, D Chen, Y Zhou… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease

B Ray, B Maloney, K Sambamurti, HK Karnati… - Translational …, 2020 - nature.com
Rivastigmine (or Exelon) is a cholinesterase inhibitor, currently used as a symptomatic
treatment for mild-to-moderate Alzheimer's disease (AD). Amyloid-β peptide (Aβ) generated …

Amyloid beta and microRNAs in Alzheimer's disease

N Amakiri, A Kubosumi, J Tran, PH Reddy - Frontiers in Neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive mental illness characterized by memory loss and
multiple cognitive impairments. In the last several decades, significant progress has been …

[HTML][HTML] LncRNA NEAT1 promotes Alzheimer's disease by down regulating micro-27a-3p

LX Dong, YY Zhang, HL Bao, Y Liu… - American journal of …, 2021 - ncbi.nlm.nih.gov
Objective: Alzheimer's disease (AD) is a common neurodegenerative disease. This study
was designed to investigate the roles of lncRNA NEAT1/miR-27a-3p axis in AD. Methods …

[HTML][HTML] The role of synaptic microRNAs in Alzheimer's disease

S Kumar, PH Reddy - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2020 - Elsevier
Structurally and functionally active synapses are essential for neurotransmission and for
maintaining normal synaptic and cognitive functions. Researchers have found that synaptic …

RNA dynamics in Alzheimer's disease

A Rybak-Wolf, M Plass - Molecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
heavily burdens healthcare systems worldwide. There is a significant requirement to …