Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents
WO Castillo-Ordoñez, N Cajas-Salazar… - Neural regeneration …, 2024 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …
The Hidden Players: Shedding Light on the Significance of Post-Translational Modifications and miRNAs in Alzheimer's Disease Development
Alzheimer's disease (AD) is the most prevalent, expensive, lethal, and burdening
neurodegenerative disease of this century. The initial stages of this disease are …
neurodegenerative disease of this century. The initial stages of this disease are …
Non-coding RNAs: Emerging from the discovery to therapeutic applications
B Baptista, M Riscado, JA Queiroz, C Pichon… - Biochemical …, 2021 - Elsevier
The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data
continuously emerging, regarding their diverse types, applications, and roles. Particular …
continuously emerging, regarding their diverse types, applications, and roles. Particular …
[HTML][HTML] MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease
Abstract Background MicroRNA-455-3p is one of the highly conserved miRNAs involved in
multiple cellular functions in humans and we explored its relevance to learning and memory …
multiple cellular functions in humans and we explored its relevance to learning and memory …
CircLPAR1/miR-212-3p/ZNF217 feedback loop promotes amyloid β-induced neuronal injury in Alzheimer's Disease
L Wu, Q Du, C Wu - Brain Research, 2021 - Elsevier
Abstract Background Alzheimer's Disease (AD) is a neurodegenerative disorder
characterized by progressive memory loss and cognition and language impairment …
characterized by progressive memory loss and cognition and language impairment …
The role of butyrylcholinesterase and iron in the regulation of cholinergic network and cognitive dysfunction in Alzheimer's disease pathogenesis
J Jasiecki, M Targońska, B Wasąg - International Journal of Molecular …, 2021 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia in elderly individuals, is
marked by progressive neuron loss. Despite more than 100 years of research on AD, there …
marked by progressive neuron loss. Despite more than 100 years of research on AD, there …
Epigenetics: Recent advances and its role in the treatment of Alzheimer's disease
X Xiao, X Liu, B Jiao - Frontiers in Neurology, 2020 - frontiersin.org
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …
Uncovering the impact of noncoding variants in neurodegenerative brain diseases
A Frydas, E Wauters, J van der Zee… - Trends in Genetics, 2022 - cell.com
Neurodegenerative brain diseases (NBDs) are characterized by cognitive decline and
movement impairments caused by neuronal loss in different brain regions. A large fraction of …
movement impairments caused by neuronal loss in different brain regions. A large fraction of …
Targeting increased levels of APP in down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse …
Objective Recent clinical trials targeting amyloid beta (Aβ) and tau in Alzheimer's disease
(AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and …
(AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and …
lncRNA SNHG1 knockdown alleviates amyloid-β-induced neuronal injury by regulating ZNF217 via sponging miR-361-3p in Alzheimer's disease
Y Gao, N Zhang, C Lv, N Li, X Li… - Journal of Alzheimer's …, 2020 - content.iospress.com
Background: Long noncoding RNAs have been proven to play an important role in the
progression of Alzheimer's disease (AD). However, the function of small nucleolar RNA host …
progression of Alzheimer's disease (AD). However, the function of small nucleolar RNA host …