Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

WO Castillo-Ordoñez, N Cajas-Salazar… - Neural regeneration …, 2024 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …

The Hidden Players: Shedding Light on the Significance of Post-Translational Modifications and miRNAs in Alzheimer's Disease Development

R Singh, J Hussain, A Kaur, BG Jamdare… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent, expensive, lethal, and burdening
neurodegenerative disease of this century. The initial stages of this disease are …

Non-coding RNAs: Emerging from the discovery to therapeutic applications

B Baptista, M Riscado, JA Queiroz, C Pichon… - Biochemical …, 2021 - Elsevier
The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data
continuously emerging, regarding their diverse types, applications, and roles. Particular …

[HTML][HTML] MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease

S Kumar, H Morton, N Sawant, E Orlov, LE Bunquin… - Redox biology, 2021 - Elsevier
Abstract Background MicroRNA-455-3p is one of the highly conserved miRNAs involved in
multiple cellular functions in humans and we explored its relevance to learning and memory …

CircLPAR1/miR-212-3p/ZNF217 feedback loop promotes amyloid β-induced neuronal injury in Alzheimer's Disease

L Wu, Q Du, C Wu - Brain Research, 2021 - Elsevier
Abstract Background Alzheimer's Disease (AD) is a neurodegenerative disorder
characterized by progressive memory loss and cognition and language impairment …

The role of butyrylcholinesterase and iron in the regulation of cholinergic network and cognitive dysfunction in Alzheimer's disease pathogenesis

J Jasiecki, M Targońska, B Wasąg - International Journal of Molecular …, 2021 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia in elderly individuals, is
marked by progressive neuron loss. Despite more than 100 years of research on AD, there …

Epigenetics: Recent advances and its role in the treatment of Alzheimer's disease

X Xiao, X Liu, B Jiao - Frontiers in Neurology, 2020 - frontiersin.org
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …

Uncovering the impact of noncoding variants in neurodegenerative brain diseases

A Frydas, E Wauters, J van der Zee… - Trends in Genetics, 2022 - cell.com
Neurodegenerative brain diseases (NBDs) are characterized by cognitive decline and
movement impairments caused by neuronal loss in different brain regions. A large fraction of …

Targeting increased levels of APP in down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse …

XQ Chen, A Salehi, ML Pearn, C Overk… - Alzheimer's & …, 2021 - Wiley Online Library
Objective Recent clinical trials targeting amyloid beta (Aβ) and tau in Alzheimer's disease
(AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and …

lncRNA SNHG1 knockdown alleviates amyloid-β-induced neuronal injury by regulating ZNF217 via sponging miR-361-3p in Alzheimer's disease

Y Gao, N Zhang, C Lv, N Li, X Li… - Journal of Alzheimer's …, 2020 - content.iospress.com
Background: Long noncoding RNAs have been proven to play an important role in the
progression of Alzheimer's disease (AD). However, the function of small nucleolar RNA host …