Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under
investigation for multiple nervous system disorders, including Alzheimer's disease (AD) …

Background: The Tg4-42 mouse model for sporadic Alzheimer's disease (AD) has unique
features, as the neuronal expression of wild type N-truncated Aß4–42 induces an AD-typical …

Neurodegenerative diseases are a diverse group of diseases that are now one of the
leading causes of morbidity in the elderly population. These diseases include Alzheimer's …

Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by the
accumulation of β-amyloid (Aβ) plaques and tau phosphorylation-induced neurofibrillary …

Background: Neurodegenerative diseases, such as Alzheimer's disease patients (AD),
Huntington's disease (HD) and Parkinson's disease (PD), are common causes of morbidity …

Manganese (Mn) is an essential heavy metal in the human body, while excess Mn leads to
neurotoxicity, as observed in this study, where 100 µM of Mn was administered to the human …

Background: There is an urgent need for noninvasive, cost-effective biomarkers for
Alzheimer's disease (AD), such as bloodbased biomarkers. They will not only support the …

Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved
regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with age. A wealth of
evidence indicates that the amyloid β (Aβ) aggregates result from dyshomeostasis between …

Familial Alzheimer's disease (fAD) mutations in the amyloid-β protein precursor (AβPP)
enhance brain AβPP C-Terminal Fragment (CTF) levels to inhibit lysosomal v-ATPase …