Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Covering: 2013 to 2021 As the characteristic metabolites of Euphorbia plants, Euphorbia
diterpenoids have always been a hot topic in related science communities due to their …

Proteolysis Targeting Chimera (PROTAC) is an emerging approach to selectively degrading
target proteins by utilizing endogenous proteasome 1. Since PROTACs can degrade target …

Two novel diterpenoids, one with a rearranged trans, trans-fused tricyclo [10.3. 0.04, 6]
pentadecane framework (1) and the other with an unprecedented 15 S configuration (2) …

In our ongoing work on the identification of potent anti-inflammatory agents, we designed
and synthesized three series of lathyrane diterpenoid hybrids in which the lathyrane …

An efficient Ir-catalyzed biomimetic method for photoisomerization of cyclopropane in
lathyrane-type Euphorbia diterpenes is reported. Lathyrane diterpenes featuring the trans …

The Euphorbia plants are the focus of natural product drug discovery because of their
fascinating structural diversity and broad biological activities. Here we reported the …

Lathyrol is a core scaffold structure of many lathyrane diterpenoids with potent anti-
inflammatory activity isolated from Euphorbia lathyrism. It was chosen as a framework to …

Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and
mortality worldwide. The aerial parts of Euphorbia grantii Oliv. were extracted with methanol …

Lathyrane diterpenoids are one of the primary types of secondary metabolites present in the
genus Euphorbia and one of the largest groups of diterpenes. They are characterized by …