The prevalence of obesity and associated diseases has reached pandemic levels. Obesity is
often associated with overnutrition and a sedentary lifestyle, but clearly other factors also …

The escalating prevalence of male infertility and decreasing trend in sperm quality have
been correlated with rapid industrialisation and the associated discharge of an excess of …

An emerging concern is the influences of early life exposure to environmental toxicants on
offspring characteristics in later life. Since recent evidence suggests a transgenerational …

One of the most important developing cell types in any biological system is the gamete
(sperm and egg). The transmission of phenotypes and optimally adapted physiology to …

Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene
expression without modifying the DNA sequence. It is commonly accepted that the …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

Obesity and metabolic disorders have become a worldwide pandemic affecting millions of
people. Although obesity is a multifaceted disease, there is growing evidence supporting the …

In the last 40 years, male reproductive health—which is very sensitive to both environmental
exposure and metabolic status—has deteriorated and the poor sperm quality observed has …

Background Paternal lifestyle choices and male exposure history have a critical influence on
the health and fitness of the next generation. Accordingly, defining the processes of germline …

Because epigenetics is a critical component for gene expression, the hypothesis was tested
that DNA methylation alterations are dynamic and continually change throughout …