Accumulating epidemiological evidence shows that being either overweight or obese, in
other words having excess body weight (EBW), is associated with an increased risk of …

Postnatal growth and development of the human body and its specific organs are regulated
by a complex network of local and systemic factors which is poorly understood. This review …

IGF-I is a multipotent growth factor with important actions on normal tissue growth and
regeneration. In addition, IGF-I has been suggested to have beneficial effects on glucose …

Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood,
puberty, and young adulthood proceeds via multiple convergent and divergent pathways in …

Exercise is a robust physiological stimulator of the pituitary secretion of growth hormone
(GH), and within approximately 15 min after the onset of exercise, plasma GH starts to …

At present, the circulating bioactivity of insulin-like growth factor I (IGF-I) is estimated by
immunological measurements of IGF-I levels. However, immunoassays ignore the modifying …

The influence of initial training status on the response of circulating insulin-like growth factor
(IGF) and its binding proteins (IGFBP) to prolonged physical training was studied in young …

Circulating IGF-I is correlated with fitness, but results of prospective exercise training studies
have been inconsistent, showing both increases and decreases in IGF-I. We hypothesized …

Context Anorexia nervosa (AN) can cause severe undernutrition associated with alterations
in the IGF axis. Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) …

Biochemical assessment of a patient for acromegaly aims to definitively establish or exclude
the presence of growth hormone excess. Whether applied to a newly recognized patient or …