Background Despite their origins as selfish parasitic sequences, some transposons in the
human genome have been co-opted to serve as regulatory elements, contributing to the …

Background Interferon (IFN) responses are critical in the resolution of viral infections and are
actively targeted by many viruses. They also play a role in inducing protective responses …

Mapping genetic interactions is essential for determining gene function and defining novel
biological pathways. We report a simple to use CRISPR interference (CRISPRi) based …

Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe
neurodevelopmental phenotypes with elusive mechanisms in humans. The most common …

In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a
suitable tool to identify the role of specific genes. The general consensus implies that only …

Toxicity of accumulating substrates is a significant problem in several disorders of valine and
isoleucine degradation notably short‐chain enoyl‐CoA hydratase (ECHS1 or crotonase) …

Glutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no
pharmacological treatments. A novel strategy to treat this disease is to divert the toxic …

Regulatory networks underlying innate immunity continually face selective pressures to
adapt to new and evolving pathogens. Transposable elements (TEs) can affect immune …

Background: Filopodia are dynamic, finger-like actin-filament bundles that overcome
membrane tension by forces generated through actin polymerization at their tips to allow …

Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe
neurodevelopmental phenotypes with elusive mechanisms in humans. The most common …