Three different barriers are formed between the cerebrovascular and the brain parenchyma:
the blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the …

Population aging is occurring rapidly worldwide, challenging the global economy and
healthcare services. Brain aging is a significant contributor to various age-related …

Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial
dysfunction, reduced NAD+/NADH (redox) ratio, and postmitotic senescence. Sirtuins are …

Creatine monohydrate (CrM) is one of the most widely used nutritional supplements among
active individuals and athletes to improve high-intensity exercise performance and training …

How aging affects cells of the human brain active milieu remains largely unknown. Here, we
analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older …

In inborn errors of metabolism, such as amino acid breakdown disorders, loss of function
mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of …

Ammonia is one of the most serious environmental stressors which severely affect fishery
production. Ammonia toxicity to fish has a tight relationship with oxidative stress …

Creatine supplementation has been put forward as a possible aid to cognition, particularly
for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However …

Cognitive impairment in the elderly is associated with alterations in bile acid (BA)
metabolism. In this study, we observe elevated levels of serum conjugated primary bile acids …

Aquaporins (Aqp) 1 and Aqp3 are the representatives of two types of aquaporins (classical
aquaporin and aquaglyceroporin) and have been proven to potentially facilitate ammonia …