Immunity and inflammation in atherosclerosis
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …
Homocysteine modification in protein structure/function and human disease
H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
The role of B cells in atherosclerosis
AP Sage, D Tsiantoulas, CJ Binder… - Nature Reviews Cardiology, 2019 - nature.com
The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …
Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis
X Sun, JS Seidman, P Zhao, TD Troutman, NJ Spann… - Cell metabolism, 2020 - cell.com
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …
Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis–novel insights and future directions in diagnosis and therapy
We provide an up-to-date overview of current topics surrounding oxidized low-density
lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at …
lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at …
The influence of innate and adaptive immune responses on atherosclerosis
JL Witztum, AH Lichtman - Annual Review of Pathology …, 2014 - annualreviews.org
Both the chronic development of atherosclerotic lesions and the acute changes in lesion
phenotype that lead to clinical cardiovascular events are significantly influenced by the …
phenotype that lead to clinical cardiovascular events are significantly influenced by the …
Role of inflammation and immunity in hypertension: recent epidemiological, laboratory, and clinical evidence
A Caillon, EL Schiffrin - Current hypertension reports, 2016 - Springer
Inflammation has been shown to play an important role in the mechanisms involved in the
pathogenesis of hypertension. Accordingly, innate and adaptive immune responses …
pathogenesis of hypertension. Accordingly, innate and adaptive immune responses …
Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis
H Ait-Oufella, AP Sage, Z Mallat, A Tedgui - Circulation research, 2014 - Am Heart Assoc
Chronic inflammation in response to lipoprotein accumulation in the arterial wall is central in
the development of atherosclerosis. Both innate and adaptive immunity are involved in this …
the development of atherosclerosis. Both innate and adaptive immunity are involved in this …
Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody
D Frescas, CM Roux, S Aygun-Sunar… - Proceedings of the …, 2017 - National Acad Sciences
Studying the phenomenon of cellular senescence has been hindered by the lack of
senescence-specific markers. As such, detection of proteins informally associated with …
senescence-specific markers. As such, detection of proteins informally associated with …
Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events
Objectives: This study sought to assess the long-term predictive value and net
reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation …
reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation …