Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …

The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …

The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

In eukaryotes, RNA polymerase (Pol) II transcribes chromatin and must move past
nucleosomes, often resulting in nucleosome displacement. How Pol II unwraps the DNA …

Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …

Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

Tumor suppressors are mostly defined by inactivating mutations in tumors, yet little is known
about their epigenetic features in normal cells. Through integrative analysis of 1,134 …