Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice
carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations …

Excessive neural variability of sensory responses is a hallmark of atypical sensory
processing in autistic individuals with cascading effects on other core autism symptoms but …

The thalamus is the main gateway for sensory information from the periphery to the
mammalian cerebral cortex. A major conundrum has been the discrepancy between the …

Intracortical microelectrodes have become a useful tool in neuroprosthetic applications in
the clinic and to understand neurological disorders in basic neurosciences. Many of these …

Highlights•The influence of sensory feedback on motor output is subject to constant
modulation.•Sensory gain control comes in many forms and serves diverse functions across …

The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the
surface of most eukaryotic cells. It plays a key role in cell migration, but the underlying …

To investigate which activity patterns in sensory cortex are relevant for perceptual decision-
making, we combined two-photon calcium imaging and targeted two-photon optogenetics to …

Chronic pain is a complex experience with multifaceted behavioral manifestations, often
leading to pain avoidance at the expense of reward approach. How pain facilitates …