Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions,
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …

This protocol describes a primary neuronal model of formation of α-synuclein (α-syn)
aggregates that recapitulate features of the Lewy bodies and Lewy neurites found in …

Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease,
but the evidence for their association with other neurodegenerative disorders is limited …

Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

Abstract α-Synuclein is the major component of filamentous inclusions that constitute the
defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular …

Inclusions composed of α-synuclein (α-syn), ie, Lewy bodies (LBs) and Lewy neurites (LNs),
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …

The accumulation of misfolded proteins is a fundamental pathogenic process in
neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …