Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
KC Luk, V Kehm, J Carroll, B Zhang, P O'Brien… - Science, 2012 - science.org
Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions,
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like …
This protocol describes a primary neuronal model of formation of α-synuclein (α-syn)
aggregates that recapitulate features of the Lewy bodies and Lewy neurites found in …
aggregates that recapitulate features of the Lewy bodies and Lewy neurites found in …
The many faces of α-synuclein: from structure and toxicity to therapeutic target
HA Lashuel, CR Overk, A Oueslati… - Nature Reviews …, 2013 - nature.com
Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
A Ciechanover, YT Kwon - Experimental & molecular medicine, 2015 - nature.com
Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …
Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease,
but the evidence for their association with other neurodegenerative disorders is limited …
but the evidence for their association with other neurodegenerative disorders is limited …
Ferroptosis and cell death mechanisms in Parkinson's disease
Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …
Prion-like spreading of pathological α-synuclein in brain
M Masuda-Suzukake, T Nonaka, M Hosokawa… - Brain, 2013 - academic.oup.com
Abstract α-Synuclein is the major component of filamentous inclusions that constitute the
defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular …
defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular …
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
Inclusions composed of α-synuclein (α-syn), ie, Lewy bodies (LBs) and Lewy neurites (LNs),
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
KC Luk, VM Kehm, B Zhang, P O'Brien… - Journal of Experimental …, 2012 - rupress.org
The accumulation of misfolded proteins is a fundamental pathogenic process in
neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α …
neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α …
[HTML][HTML] How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using …
ST Kumar, S Jagannath, C Francois… - Neurobiology of …, 2020 - Elsevier
Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …