Alpha‐synucleinopathies (ASP) are neurodegenerative disorders, characterized by
accumulation of misfolded α‐synuclein, selective neuronal loss, and extensive gliosis. It is …

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Considerable evidence supports the release of pathogenic aggregates of the neuronal
protein α-Synuclein (αSyn) into the extracellular space. While this release is proposed to …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Braak's prion-like theory fundamentally subverts the understanding of Parkinson's disease
(PD). Emerging evidence shows that pathologic α-synuclein (α-syn) is a prion-like protein …

Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …