Braak's prion-like theory fundamentally subverts the understanding of Parkinson's disease
(PD). Emerging evidence shows that pathologic α-synuclein (α-syn) is a prion-like protein …

Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …

The distinct protein aggregates that are found in Alzheimer's, Parkinson's, Huntington's and
prion diseases seem to cause these disorders. Small intermediates—soluble oligomers—in …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Cytoplasmic inclusions containing α-synuclein (α-Syn) fibrils, referred to as Lewy bodies
(LBs), are the signature neuropathological hallmarks of Parkinson's disease (PD). Although …

Since the discovery and isolation of α-synuclein (α-syn) from human brains, it has been
widely accepted that it exists as an intrinsically disordered monomeric protein. Two recent …

Studies of Parkinson's disease (PD) have been hindered by lack of access to affected
human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem …

The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an
association with pesticides and other environmental toxins, and biochemical studies …

Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-
synucleinopathies, such as Parkinson's disease, in which α-synuclein fibrils are a …

Parkinson's disease (PD) is characterized by the accumulation of α-synuclein (α-syn) within
Lewy body inclusions in the nervous system. There are currently no disease-modifying …