Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia
nigra and the formation of Lewy body inclusions containing aggregated α-synuclein. Efforts …

The deposition of the abundant presynaptic brain protein α-synuclein as fibrillary aggregates
in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders …

The progressive, neurodegenerative process underlying idiopathic Parkinson's disease is
associated with the formation of proteinaceous inclusion bodies that involve a few …

Summary α-Synuclein (α-syn) aggregation is a key event in Parkinson's disease (PD).
Mutations in glycosphingolipid (GSL)-degrading glucocerebrosidase are risk factors for PD …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are usually associated with
loss of dopaminergic neurons. Loss of substantia nigra neurons and presence of Lewy body …

Parkinson's disease is a common neurodegenerative syndrome characterized by loss of
dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal …

Two mutations in the gene encoding α-synuclein have been linked to early-onset
Parkinson's disease 1, 2, 3 (PD). α-Synuclein is a component of Lewy bodies, the fibrous …

Helicobacter pylori infection is associated with a variety of clinical outcomes including
gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but …

In recent years, two developments have imparted a new direction to research on the
aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …