A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly
BI Giasson, IVJ Murray, JQ Trojanowski… - Journal of Biological …, 2001 - ASBMB
Neuronal and oligodendrocytic aggregates of fibrillar α-synuclein define several diseases of
the nervous system. It is likely that these inclusions impair vital metabolic processes and …
the nervous system. It is likely that these inclusions impair vital metabolic processes and …
Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein
BI Giasson, JE Duda, SM Quinn, B Zhang… - Neuron, 2002 - cell.com
Abstract α-Synucleinopathies are neurodegenerative disorders that range pathologically
from the demise of select groups of nuclei to pervasive degeneration throughout the …
from the demise of select groups of nuclei to pervasive degeneration throughout the …
The contribution of alpha synuclein to neuronal survival and function–Implications for Parkinson's disease
MJ Benskey, RG Perez… - Journal of …, 2016 - Wiley Online Library
The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
Aggregated α-synuclein proteins form brain lesions that are hallmarks of neurodegenerative
synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of …
synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of …
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
MG Spillantini, RA Crowther, R Jakes, NJ Cairns… - Neuroscience …, 1998 - Elsevier
α-Synuclein forms the major component of Lewy bodies and Lewy neurites, the defining
neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies …
neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies …
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update
To date, molecular genetic analyses have identified over 500 distinct DNA variants in five
disease genes associated with familial Parkinson disease; α‐synuclein (SNCA), parkin …
disease genes associated with familial Parkinson disease; α‐synuclein (SNCA), parkin …
Synergistic interactions between Aβ, tau, and α-synuclein: acceleration of neuropathology and cognitive decline
LK Clinton, M Blurton-Jones, K Myczek… - Journal of …, 2010 - Soc Neuroscience
Alzheimer's disease (AD), the most prevalent age-related neurodegenerative disorder, is
characterized pathologically by the accumulation of β-amyloid (Aβ) plaques and tau-laden …
characterized pathologically by the accumulation of β-amyloid (Aβ) plaques and tau-laden …
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
Parkinson's disease is a movement disorder characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in …
neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in …
[HTML][HTML] Distinct α-synuclein strains differentially promote tau inclusions in neurons
Many neurodegenerative diseases are characterized by the accumulation of insoluble
protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease …
protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease …
The emerging role of α-synuclein truncation in aggregation and disease
ZA Sorrentino, BI Giasson - Journal of Biological Chemistry, 2020 - ASBMB
α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …