Neuronal and oligodendrocytic aggregates of fibrillar α-synuclein define several diseases of
the nervous system. It is likely that these inclusions impair vital metabolic processes and …

Abstract α-Synucleinopathies are neurodegenerative disorders that range pathologically
from the demise of select groups of nuclei to pervasive degeneration throughout the …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

Aggregated α-synuclein proteins form brain lesions that are hallmarks of neurodegenerative
synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of …

α-Synuclein forms the major component of Lewy bodies and Lewy neurites, the defining
neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies …

To date, molecular genetic analyses have identified over 500 distinct DNA variants in five
disease genes associated with familial Parkinson disease; α‐synuclein (SNCA), parkin …

Alzheimer's disease (AD), the most prevalent age-related neurodegenerative disorder, is
characterized pathologically by the accumulation of β-amyloid (Aβ) plaques and tau-laden …

Parkinson's disease is a movement disorder characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in …

Many neurodegenerative diseases are characterized by the accumulation of insoluble
protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …