Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
KA Conway, JC Rochet, RM Bieganski, PT Lansbury Jr - Science, 2001 - science.org
The substantia nigra in Parkinson's disease (PD) is depleted of dopaminergic neurons and
contains fibrillar Lewy bodies comprising primarily α-synuclein. We screened a library to …
contains fibrillar Lewy bodies comprising primarily α-synuclein. We screened a library to …
Synucleins are developmentally expressed, and α-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
DD Murphy, SM Rueter, JQ Trojanowski… - Journal of …, 2000 - Soc Neuroscience
α-, β-, and γ-Synuclein, a novel family of neuronal proteins, has become the focus of
research interest because α-synuclein has been increasingly implicated in the pathogenesis …
research interest because α-synuclein has been increasingly implicated in the pathogenesis …
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
TG Beach, CH Adler, LF Lue, LI Sue, J Bachalakuri… - Acta …, 2009 - Springer
The two current major staging systems in use for Lewy body disorders fail to classify up to
50% of subjects. Both systems do not allow for large numbers of subjects who have Lewy …
50% of subjects. Both systems do not allow for large numbers of subjects who have Lewy …
[HTML][HTML] Anthocyanins and their metabolites as therapeutic agents for neurodegenerative disease
AN Winter, PC Bickford - Antioxidants, 2019 - mdpi.com
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific …
amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific …
Dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative
dementia in older people. It is part of the range of clinical presentations that share a neuritic …
dementia in older people. It is part of the range of clinical presentations that share a neuritic …
Pathoanatomy of Parkinson's disease
H Braak, E Braak - Journal of neurology, 2000 - Springer
Parkinson's disease is a widespread degenerative illness affecting the human central,
peripheral, and enteric nervous systems. The underlying pathological process progresses …
peripheral, and enteric nervous systems. The underlying pathological process progresses …
Where does parkinson disease pathology begin in the brain?
K Del Tredici, U Rüb, RAI De Vos… - … of Neuropathology & …, 2002 - academic.oup.com
The substantia nigra is not the induction site in the brain of the neurodegenerative process
underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 …
underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 …
Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using α‐synuclein immunohistochemistry
RL Hamilton - Brain pathology, 2000 - Wiley Online Library
Antibodies to α‐synuclein (AS) now provide a sensitive and specific method for the detection
of Lewy bodies (LBs) and their use will allow a more accurate determination of the …
of Lewy bodies (LBs) and their use will allow a more accurate determination of the …
[HTML][HTML] In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease
DL Price, A Khan, R Angers, A Cardenas… - npj Parkinson's …, 2023 - nature.com
Direct targeting of alpha-synuclein (ASYN) has emerged as a disease-modifying strategy for
Parkinson's disease and other synucleinopathies which is being approached using both …
Parkinson's disease and other synucleinopathies which is being approached using both …
The threshold theory for Parkinson's disease
S Engelender, O Isacson - Trends in neurosciences, 2017 - cell.com
Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …
In contrast to the current ascending theory where α-synuclein would propagate from neuron …