The salutary intersection of fundamental cell biology with the study of disease is well
illustrated by the emerging elucidation of neurodegenerative disorders. Novel mechanisms …

Recombinant adeno-associated viral vectors display efficient tropism for transduction of the
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …

Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of
pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy …

The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates
called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal …

Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …

The intrinsically disordered protein α-synuclein plays a key role in the pathogenesis of
Parkinson's disease (PD). We show here that the native state of α-synuclein consists of a …

α-Synuclein is the major component of Lewy bodies and Lewy neurites, which are granular
and filamentous protein inclusions that are the defining pathological features of several …

Increasingly, evidence argues that many neurodegenerative diseases, including
progressive supranuclear palsy (PSP), are caused by prions, which are alternatively folded …

Parkinson's disease (PD) and other related disorders are characterized by the accumulation
of fibrillar aggregates of α‐synuclein protein (α‐syn) inside brain cells. It is likely that the …

A continuous threat to cell function and viability is the contain components of the ubiquitin-
proteasome degraaccumulation in cells of proteins with highly abnormal dative pathway and …