Role of actin depolymerizing factor cofilin in Aspergillus fumigatus oxidative stress response and pathogenesis

X Jia, X Zhang, Y Hu, M Hu, S Tian, X Han, Y Sun… - Current genetics, 2018 - Springer
Aspergillus fumigatus is a major fungal pathogen that is responsible for approximately 90%
of human aspergillosis. Cofilin is an actin depolymerizing factor that plays crucial roles in …

Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells

M Bertuzzi, GJ Howell, DD Thomson, R Fortune-Grant… - Iscience, 2024 - cell.com
Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings,
representing a constant, possibly fatal, threat to respiratory health. The small size of Af …

Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs

J Pollmächer, S Timme, S Schuster, AA Brakhage… - Scientific reports, 2016 - nature.com
Microbial invaders are ubiquitously present and pose the constant risk of infections that are
opposed by various defence mechanisms of the human immune system. A tight regulation of …

Could the Lung Be a Gateway for Amphotericin B to Attack the Army of Fungi?

BF de Carvalho Patricio, JO da Silva Lopes Pereira… - Pharmaceutics, 2022 - mdpi.com
Fungal diseases are a significant cause of morbidity and mortality worldwide, primarily
affecting immunocompromised patients. Aspergillus, Pneumocystis, and Cryptococcus are …

Regulation of Surfactant Protein Gene Expression by Aspergillus fumigatus in NCl-H441 Cells

N Schiefermeier-Mach, L Heinrich, L Lechner… - Microorganisms, 2023 - mdpi.com
Aspergillus fumigatus is an opportunistic fungal pathogen that causes serious lung diseases
in immunocompromised patients. The lung surfactant produced by alveolar type II and Clara …

[HTML][HTML] Up-regulation of Dectin-1 in airway epithelial cells promotes mice defense against invasive pulmonary aspergillosis

ZC Liu, M Wang, WK Sun, D Xia, MM Tan… - … Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Introduction: With the growing number of immunocompromised patients, the incidence of
invasive pulmonary aspergillosis increases. Innate immunity plays a significant role in …

[HTML][HTML] Transcriptomic reprogramming of genus Paracoccidioides in dimorphism and host niches

AH Tavares, L Fernandes, AL Bocca… - Fungal Genetics and …, 2015 - Elsevier
The thermodimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii are the
etiologic agents of Paracoccidioidomycosis (PCM), the most important endemic systemic …

Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus

CO Morton, S Wurster, M Fliesser, F Ebel… - International Journal of …, 2018 - Elsevier
Interactions between fungal pathogens such as Aspergillus fumigatus with host alveolar
epithelium and innate immune cells are crucial in the defense against opportunistic fungal …

Ghrelin ameliorates the human alveolar epithelial A549 cell apoptosis induced by lipopolysaccharide

C Huang, H Zheng, W He, G Lu, X Li, Y Deng… - Biochemical and …, 2016 - Elsevier
Ghrelin is a gastric acyl-peptide that plays an inhibitory role in cell apoptosis. Herein we
investigate the protective effects of ghrelin in LPS-induced apoptosis of human alveolar …

Potential Proallergenic Activity of Phytopathogenic Erysiphe palczewskii and Erysiphe convolvuli in in vitro Studies

M Sztandera-Tymoczek… - Journal of …, 2023 - Taylor & Francis
Purpose Allergic diseases have reached epidemic proportions globally, affecting nearly
30% of the world's population. One of the most prominent sources of allergens is fungi …