Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
Marine natural products in clinical use
Marine natural products are potent and promising sources of drugs among other natural
products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in …
products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in …
The extracellular matrix in skin inflammation and infection
K Pfisterer, LE Shaw, D Symmank… - Frontiers in cell and …, 2021 - frontiersin.org
The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …
Macrophage polarization in chronic inflammatory diseases: killers or builders?
L Parisi, E Gini, D Baci, M Tremolati… - Journal of …, 2018 - Wiley Online Library
Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …
in the first‐line defence against the pathogens and modulating homeostatic and …
The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity
V Poltavets, M Kochetkova, SM Pitson… - Frontiers in …, 2018 - frontiersin.org
The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …
themselves. It is highly heterogenous, comprising a cellular component that includes …
[HTML][HTML] Effect of stromal cells in tumor microenvironment on metastasis initiation
The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
Purpose Tumor associated macrophages (TAMs) are considered with the capacity to have
both negative and positive effects on tumor growth. The prognostic value of TAM for survival …
both negative and positive effects on tumor growth. The prognostic value of TAM for survival …
Tumor macrophages are pivotal constructors of tumor collagenous matrix
R Afik, E Zigmond, M Vugman, M Klepfish… - Journal of Experimental …, 2016 - rupress.org
Tumor-associated macrophages (TAMs) promote tumor development, invasion, and
dissemination by various mechanisms. In this study, using an orthotopic colorectal cancer …
dissemination by various mechanisms. In this study, using an orthotopic colorectal cancer …
Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
AM Steitz, A Steffes, F Finkernagel, A Unger… - Cell death & …, 2020 - nature.com
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …
Shaping up the tumor microenvironment with cellular fibronectin
G Efthymiou, A Saint, M Ruff, Z Rekad, D Ciais… - Frontiers in …, 2020 - frontiersin.org
Normal tissue homeostasis and architecture restrain tumor growth. Thus, for a tumor to
develop and spread, malignant cells must overcome growth-repressive inputs from …
develop and spread, malignant cells must overcome growth-repressive inputs from …