Osteopontin at the crossroads of inflammation and tumor progression
LM Castello, D Raineri, L Salmi… - Mediators of …, 2017 - Wiley Online Library
Complex interactions between tumor and host cells regulate systemic tumor dissemination,
a process that begins early at the primary tumor site and goes on until tumor cells detach …
a process that begins early at the primary tumor site and goes on until tumor cells detach …
Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression
W Donelan, PR Dominguez-Gutierrez… - Frontiers in …, 2022 - frontiersin.org
Hyaluronan (HA) is known to be a prominent component of the extracellular matrix in tumors,
and many solid cancers are characterized by aberrant HA metabolism resulting in increased …
and many solid cancers are characterized by aberrant HA metabolism resulting in increased …
Macrophages and cancer stem cells: a malevolent alliance
P Allavena, E Digifico, C Belgiovine - Molecular Medicine, 2021 - Springer
Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because
their pro-tumor and immunosuppressive functions are relevant for disease progression and …
their pro-tumor and immunosuppressive functions are relevant for disease progression and …
Three-dimensional cell cultures: the bridge between in vitro and in vivo models
O Urzì, R Gasparro, E Costanzo, A De Luca… - International Journal of …, 2023 - mdpi.com
Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …
in research, providing much fundamental information regarding cellular functions and …
The extracellular matrix: a key accomplice of cancer stem cell migration, metastasis formation, and drug resistance in PDAC
D Wang, Y Li, H Ge, T Ghadban, M Reeh, C Guengoer - Cancers, 2022 - mdpi.com
Simple Summary This review takes the extracellular matrix (ECM) as the starting point, and
describes its influence and related mechanisms on the biological behavior of pancreatic …
describes its influence and related mechanisms on the biological behavior of pancreatic …
Role of the nervous system in cancer metastasis
N Kuol, L Stojanovska, V Apostolopoulos… - Journal of Experimental & …, 2018 - Springer
Cancer remains as one of the leading cause of death worldwide. The development of cancer
involves an intricate process, wherein many identified and unidentified factors play a role …
involves an intricate process, wherein many identified and unidentified factors play a role …
Targeting tumor-associated macrophages in anti-cancer therapies: convincing the traitors to do the right thing
In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …
Therapy resistance, cancer stem cells and ECM in cancer: the matrix reloaded
Simple Summary The extracellular matrix (ECM) has emerged as a critical part of the tumor
microenvironment. This glycoprotein-and proteoglycan-rich part of the tumor serves as a …
microenvironment. This glycoprotein-and proteoglycan-rich part of the tumor serves as a …
Role of inflammation in the aging bones
Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone
loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to …
loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to …
Unraveling the ECM-immune cell crosstalk in skin diseases
The extracellular matrix (ECM) is a complex network of proteins and proteoglycans secreted
by keratinocytes, fibroblasts and immune cells. The function of the skin ECM has expanded …
by keratinocytes, fibroblasts and immune cells. The function of the skin ECM has expanded …