Macrophage (Mϕ) polarization is an essential phenomenon for the maintenance of
homeostasis and tissue repair, and represents the event by which Mϕ reach divergent …

In the last decade, understanding of cancer initiation and progression has been given much
attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can …

Macrophages in the tumor microenvironment have a substantial impact on tumor
progression. Depending on the signaling environment in the tumor, macrophages can either …

Simple Summary Transglutaminase-2 (TG2) is an enzyme primarily involved in protein cross-
linking, which has been shown to play a role in the development and progression of …

Certain types of cells possess unique characteristics such as tumor homing and prolonged
circulation in blood, which are worthy of being exploited in drug delivery carriers for cancer …

Phagocytes, such as tumor‐associated macrophages (TAM s) and tumor‐associated
neutrophils (TAN s), are abundant in the stroma of experimental and human tumors and are …

The tumor microenvironment (TME) is a complex neighborhood that consists of immune
cells, fibroblasts, pericytes, adipocytes, endothelial and neuronal cells, and the extracellular …

The nature of the tumor microenvironment (TME) influences the ability of tumor-specific T
cells to control tumor growth. In this study, we performed an unbiased comparison of the …

The stroma is a considerable part of the tumor microenvironment. Because of its complexity,
it can influence both cancer and immune cells in their behavior and cross-talk. Aside from …

The prevailing paradigm states that cancer cells acquire multiple genetic mutations in
oncogenes or tumor suppressor genes whose respective activation/up-regulation or loss of …