The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in …
A De Vita, F Recine, G Miserocchi, F Pieri… - Journal of Experimental …, 2021 - Springer
Background Soft tissue sarcomas (STS) are a rare group of solid neoplasm including among
others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic …
others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic …
M2 tumor-associated macrophages play important role in predicting response to neoadjuvant chemotherapy in triple-negative breast carcinoma
Purpose Two types of macrophages are present in tumor microenvironment. M1
macrophages exhibit potent anti-tumor properties, while M2 macrophages play the pro …
macrophages exhibit potent anti-tumor properties, while M2 macrophages play the pro …
Tumor microenvironment and nitric oxide: concepts and mechanisms
A Vedenko, K Panara, G Goldstein… - … : Molecular Players–Part …, 2020 - Springer
The cancer tissue exists not as a single entity, but as a combination of different cellular
phenotypes which, taken together, dramatically contribute to the entirety of their ecosystem …
phenotypes which, taken together, dramatically contribute to the entirety of their ecosystem …
Re-polarisation of macrophages within collective tumour cell migration: a multiscale moving boundary approach
Cancer invasion of the surrounding tissue is a multiscale process of collective cell
movement that involves not only tumour cells but also other immune cells in the …
movement that involves not only tumour cells but also other immune cells in the …
Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue
JO Jones, WM Moody, JD Shields - Molecular oncology, 2021 - Wiley Online Library
Successful establishment of a tumour relies on a cascade of interactions between cancer
cells and stromal cells within an evolving microenvironment. Both immune and nonimmune …
cells and stromal cells within an evolving microenvironment. Both immune and nonimmune …
Breaking the stromal barrier in pancreatic cancer: Advances and challenges
M Chakkera, JB Foote, B Farran… - Biochimica et Biophysica …, 2023 - Elsevier
Pancreatic cancer (PC) remains a leading cause of mortality worldwide due to the absence
of early detection methods and the low success rates of traditional therapeutic strategies …
of early detection methods and the low success rates of traditional therapeutic strategies …
Elevated Levels of TNF-α and decreased levels of CD68-positive macrophages in primary tumor tissues are unfavorable for the survival of patients with …
Y Yu, L Ke, WX Xia, Y Xiang, X Lv… - Technology in cancer …, 2019 - journals.sagepub.com
Due to the critical role of inflammation in nasopharyngeal carcinoma, we aim to investigate
the correlation between nasopharyngeal carcinoma prognosis and the levels of tumor …
the correlation between nasopharyngeal carcinoma prognosis and the levels of tumor …
3D model of the early melanoma microenvironment captures macrophage transition into a tumor-promoting phenotype
Simple Summary We developed a “tumor-in-a-dish” experimental system to study the early
events favoring tumor growth and suppression of the immune response in metastatic …
events favoring tumor growth and suppression of the immune response in metastatic …
Origin, production and molecular determinants of macrophages for their therapeutic targeting
S Chowdhury, AK Trivedi - Cell Biology International, 2023 - Wiley Online Library
Macrophages, the most heterogeneous cells of the hematopoietic system and the giant
eaters of the immune system that present either as tissue‐resident cells or infiltrated immune …
eaters of the immune system that present either as tissue‐resident cells or infiltrated immune …
Novel immunoregulatory functions of IL-18, an accomplice of TGF-β1
TGF-β1 is a pleiotropic factor exerting a strong regulatory role in several cell types, including
immune cells. In NK cells it profoundly alters the surface expression of crucial activating and …
immune cells. In NK cells it profoundly alters the surface expression of crucial activating and …