[HTML][HTML] Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Fermented foods: An update on evidence-based health benefits and future perspectives

I Diez-Ozaeta, OJ Astiazaran - Food Research International, 2022 - Elsevier
In recent years, an unstoppable trend toward minimally processed foods has increased the
popularity of fermented foods as a beneficial nutritional and functional strategy. Within food …

Neurotransmitters: emerging targets in cancer

SH Jiang, LP Hu, X Wang, J Li, ZG Zhang - Oncogene, 2020 - nature.com
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

GABAergic signaling beyond synapses: an emerging target for cancer therapy

D Huang, PB Alexander, QJ Li, XF Wang - Trends in cell biology, 2023 - cell.com
Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …

Effects of fungal based bioactive compounds on human health

N Rousta, M Aslan, M Yesilcimen Akbas… - Critical reviews in …, 2023 - Taylor & Francis
Since the first years of history, microbial fermentation products such as bread, wine, yogurt
and vinegar have always been noteworthy regarding their nutritional and health effects …

[HTML][HTML] The GABA and GABA-receptor system in inflammation, anti-tumor immune responses, and COVID-19

J Tian, DL Kaufman - Biomedicines, 2023 - mdpi.com
GABA and GABAA-receptors (GABAA-Rs) play major roles in neurodevelopment and
neurotransmission in the central nervous system (CNS). There has been a growing …

[HTML][HTML] The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: a critical reappraisal

HM Al-Kuraishy, NR Hussian, MS Al-Naimi… - … Journal of Preventive …, 2021 - ncbi.nlm.nih.gov
Background: Diabetes mellitus (DM) is an endocrine disorder characterized by
hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an …

Peripheral innervation in the regulation of glucose homeostasis

EE Lin, E Scott-Solomon, R Kuruvilla - Trends in neurosciences, 2021 - cell.com
Precise regulation of circulating glucose is crucial for human health and ensures a sufficient
supply to the brain, which relies almost exclusively on glucose for metabolic energy …

[HTML][HTML] Physiology, GABA

BE Jewett, S Sharma - 2018 - europepmc.org
Gamma-aminobutyric acid (GABA) is an amino acid that serves as the primary inhibitory
neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. It …

[HTML][HTML] Invited review: Potential effects of short-and long-term intake of fermented dairy products on prevention and control of type 2 diabetes mellitus

SF Awwad, A Abdalla, FC Howarth, L Stojanovska… - Journal of Dairy …, 2022 - Elsevier
The consumption of fermented dairy products has been linked with lowering the risk of type
2 diabetes mellitus (T2DM), but studies have yet to demonstrate a definite association. We …