Paradoxical effect of Aβ on protein levels of ABCA1 in astrocytes, microglia, and neurons isolated from C57BL/6 mice: an in vitro and in silico study to elucidate the …
Impaired cholesterol metabolism has been reported in Alzheimer's disease. Since ABCA1 is
one of the main players in the brain's cholesterol homeostasis, here we used the in-vitro and …
one of the main players in the brain's cholesterol homeostasis, here we used the in-vitro and …
Integrated molecular and quantum mechanical approach to identify novel potent natural bioactive compound against 2′-O-methyltransferase (nsp16) of SARS-CoV-2
With the advent of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
outbreak, efforts are still in progress to find out a functional cure for the infection. Among the …
outbreak, efforts are still in progress to find out a functional cure for the infection. Among the …
[HTML][HTML] In Silico Studies of Drug Discovery and Design Against COVID-19 Focusing on ACE2 and Spike Protein Virus Receptors: A Systematic Review
The emergence of COVID-19 has prompted researchers worldwide to focus on developing
drugs that specifically target ACE2 receptors and SARS-CoV-2 Spike Protein receptors …
drugs that specifically target ACE2 receptors and SARS-CoV-2 Spike Protein receptors …
In-silico design novel phenylsulfonyl furoxan and phenstatin derivatives as multi-target anti-cancer inhibitors based on 2D-QSAR, molecular docking, dynamics and …
A Guendouzi, L Belkhiri, F Djelti, ZM Zendaoui… - Molecular …, 2024 - Taylor & Francis
ABSTRACT A series of 31 hybrid of phenylsulfonyl furoxan and phenstatin (1a-j, 2a-j, 3a-j, 4
and 5) derivatives, were computationally studied as potential anti-cancer inhibitors against …
and 5) derivatives, were computationally studied as potential anti-cancer inhibitors against …
Insights from computational studies on the potential of natural compounds as inhibitors against SARS-CoV-2 spike omicron variant
AA Alzain - SAR and QSAR in Environmental Research, 2022 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (COVID-19) is a major global health emergency, with
more than six million deaths worldwide. It is becoming increasingly challenging to treat …
more than six million deaths worldwide. It is becoming increasingly challenging to treat …
[HTML][HTML] Repurposing FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, and Remdesivir as potential inhibitors against RNA dependent …
Vaccines are undoubtedly the most effective means of combating viral diseases like COVID-
19. However, there are risks associated with vaccination, such as incomplete viral …
19. However, there are risks associated with vaccination, such as incomplete viral …
In silico approach for designing novel SARS-CoV-2 inhibitors from medicinal plants
Medicinal plants belonging to Cameroon flora, could be a source for the discovery of
potential inhibitors of SARS-CoV-2. These two proteins play a pivotal role in mediating viral …
potential inhibitors of SARS-CoV-2. These two proteins play a pivotal role in mediating viral …
Biodegradation of quinoline by Nitrosomonas mobilis Ms1 through nitrification: A mechanistic study
P Chawley, S Jagadevan - Biochemical Engineering Journal, 2023 - Elsevier
Effluents from pharmaceutical and coal gasification industries contain recalcitrant aromatic
pollutants such as quinoline. Ammonia oxidizing bacteria (AOB) has been known to …
pollutants such as quinoline. Ammonia oxidizing bacteria (AOB) has been known to …
Molecular docking, molecular dynamics simulation, and MM/PBSA analysis of ginger phytocompounds as a potential inhibitor of AcrB for treating multidrug-resistant …
The emergence of Multidrug resistance (MDR) in human pathogens has defected the
existing antibiotics and compelled us to understand more about the basic science behind …
existing antibiotics and compelled us to understand more about the basic science behind …
Computational exploration of natural compounds targeting Staphylococcus aureus: inhibiting AgrA promoter binding for antimicrobial intervention
Staphylococcus aureus is a highly virulent nosocomial pathogen that poses a significant
threat to individuals exposed to healthcare settings. Due to its sophisticated machinery for …
threat to individuals exposed to healthcare settings. Due to its sophisticated machinery for …