Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions
CH Lo, LM O'Connor, GWZ Loi, EN Saipuljumri… - ACS …, 2023 - ACS Publications
Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …
Characterization of Drug with Good Glass-Forming Ability Loaded Mesoporous Silica Nanoparticles and Its Impact Toward in vitro and in vivo Studies
A Budiman, G Anastasya, AL Handini… - International Journal …, 2024 - Taylor & Francis
Solid oral dosage forms are mostly preferred in pharmaceutical formulation development
due to patient convenience, ease of product handling, high throughput, low manufacturing …
due to patient convenience, ease of product handling, high throughput, low manufacturing …
TRIAL-based combination therapies in cancers
Q Deng, L Chen, G Zhang, L Liu, SM Luo… - International …, 2024 - Elsevier
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) shows promising
therapeutic potential in cancer treatment as it is able to trigger extrinsic apoptotic pathways …
therapeutic potential in cancer treatment as it is able to trigger extrinsic apoptotic pathways …
Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor–ligand signaling complex
J Zeng, GWZ Loi, EN Saipuljumri… - Proceedings of the …, 2024 - National Acad Sciences
Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF
induced downstream signaling and regulating inflammatory response. Recent studies have …
induced downstream signaling and regulating inflammatory response. Recent studies have …
Identification of potent indolizine derivatives against Mycobacterial tuberculosis: In vitro anti-TB properties, in silico target validation, molecular docking and dynamics …
KN Venugopala, S Chandrashekharappa… - International Journal of …, 2024 - Elsevier
In the current study, two sets of compounds:(E)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-
((hydroxyimino) methyl) pyridinium derivatives (3a-3e); and (E)-3-(substitutedbenzoyl)-7 …
((hydroxyimino) methyl) pyridinium derivatives (3a-3e); and (E)-3-(substitutedbenzoyl)-7 …
Immunofluorescence-Based Assay for High-Throughput Analysis of Multidrug Resistance Markers in Non-Small Cell Lung Carcinoma Patient-Derived Cells
J Dinić, A Podolski-Renić, M Dragoj… - Diagnostics, 2023 - mdpi.com
Lung cancer remains the leading cause of cancer death globally, with non-small cell lung
cancer (NSCLC) accounting for the majority of cases. Multidrug resistance (MDR), often …
cancer (NSCLC) accounting for the majority of cases. Multidrug resistance (MDR), often …
Identifying alkaline phosphatase inhibitory potential of cyclooxygenase-2 inhibitors: Insights from molecular docking, MD simulations, molecular expression analysis in …
Abstract Alkaline phosphatases (APs, EC 3.1. 3.1) belong to a superfamily of biological
macromolecules that dephosphorylate many phosphometabolites and phosphoproteins and …
macromolecules that dephosphorylate many phosphometabolites and phosphoproteins and …
Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches
M Gu, Y Liu, P Xin, W Guo, Z Zhao, X Yang, R Ma… - Cancer Letters, 2024 - Elsevier
The gastrointestinal tract can be affected by a number of diseases that pancreatic cancer
(PC) is a malignant manifestation of them. The prognosis of PC patients is unfavorable and …
(PC) is a malignant manifestation of them. The prognosis of PC patients is unfavorable and …