Cell and circuit complexity of the external globus pallidus

CD Courtney, A Pamukcu, CS Chan - Nature neuroscience, 2023 - nature.com
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …

[HTML][HTML] Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease

J Dong, S Hawes, J Wu, W Le, H Cai - Frontiers in neural circuits, 2021 - frontiersin.org
The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for
processing motor and non-motor information through the creation of complex connections …

Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits

BM Colquitt, DP Merullo, G Konopka, TF Roberts… - Science, 2021 - science.org
INTRODUCTION The mammalian neocortex, with its distinctive six-layered structure, is
thought to enable advanced cognitive functions not seen in other animals. Yet birds, which …

Npas1+-Nkx2. 1+ neurons are an integral part of the cortico-pallido-cortical loop

ZA Abecassis, BL Berceau, PH Win… - Journal of …, 2020 - Soc Neuroscience
Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in
motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established …

Novel targets in deep brain stimulation for movement disorders

AJ Baumgartner, JA Thompson, DS Kern… - Neurosurgical …, 2022 - Springer
The neurosurgical treatment of movement disorders, primarily via deep brain stimulation
(DBS), is a rapidly expanding and evolving field. Although conventional targets including the …

Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys

M Deffains, L Iskhakova, S Katabi, SN Haber, Z Israel… - Elife, 2016 - elifesciences.org
The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal
ganglia (BG) network and together innervate BG downstream structures using GABA and …

Cellular and synaptic dysfunctions in Parkinson's disease: stepping out of the striatum

N Mallet, L Delgado, M Chazalon, C Miguelez… - Cells, 2019 - mdpi.com
The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate
in a great variety of functions, ranging from motor programming and execution to procedural …

The neural bases of vertebrate motor behaviour through the lens of evolution

SM Suryanarayana, B Robertson… - … Transactions of the …, 2022 - royalsocietypublishing.org
The primary driver of the evolution of the vertebrate nervous system has been the necessity
to move, along with the requirement of controlling the plethora of motor behavioural …

Striatal cholinergic transmission. Focus on nicotinic receptors' influence in striatal circuits

M Assous - European Journal of Neuroscience, 2021 - Wiley Online Library
The critical role of acetylcholine (ACh) in the basal ganglia is evident from the effect of
cholinergic agents in patients suffering from several related neurological disorders, such as …

Striatal direct pathway targets Npas1+ pallidal neurons

Q Cui, X Du, IYM Chang, A Pamukcu… - Journal of …, 2021 - Soc Neuroscience
The classic basal ganglia circuit model asserts a complete segregation of the two striatal
output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection …