[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?

H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics

N Singh, GR Sherin, G Mugesh - Angewandte Chemie, 2023 - Wiley Online Library
Nanozymes, nanomaterials with enzyme‐mimicking activity, have attracted tremendous
interest in recent years owing to their ability to replace natural enzymes in various …

NOX dependent ROS generation and cell metabolism

T Pecchillo Cimmino, R Ammendola… - International Journal of …, 2023 - mdpi.com
Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic
natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS …

Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?

B Halliwell - Biochemical and biophysical research communications, 2022 - Elsevier
The field of oxygen free radicals, antioxidants and reactive oxygen species (ROS) has
exploded in the past few decades, and BBRC has published several seminal papers. ROS …

[HTML][HTML] New treatment paradigms in primary biliary cholangitis

C Levy, M Manns, G Hirschfield - Clinical Gastroenterology and Hepatology, 2023 - Elsevier
Primary biliary cholangitis (PBC) is an archetypal autoimmune disease. Chronic lymphocytic
cholangitis is associated with interface hepatitis, ductopenia, cholestasis, and progressive …

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

S Afzal, AS Abdul Manap, A Attiq… - Frontiers in …, 2023 - frontiersin.org
Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …

Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity

A Özcan, O Boyman - Allergy, 2022 - Wiley Online Library
Neutrophil granulocytes, or neutrophils, are the most abundant circulating leukocytes in
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …

[HTML][HTML] Targeting DNA methylation and demethylation in diabetic foot ulcers

JY Deng, XQ Wu, WJ He, X Liao, M Tang… - Journal of Advanced …, 2023 - Elsevier
Background Poor wound healing is a significant complication of diabetes, which is
commonly caused by neuropathy, trauma, deformities, plantar hypertension and peripheral …

Elexacaftor/tezacaftor/ivacaftor corrects monocyte microbicidal deficiency in cystic fibrosis

L Cavinato, FR Luly, V Pastore… - European …, 2023 - Eur Respiratory Soc
Background Cystic fibrosis (CF), which is caused by mutations in the CF transmembrane
conductance regulator (CFTR), is characterised by chronic bacterial lung infection and …

[HTML][HTML] NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders

Y Zilberter, DR Tabuena, M Zilberter - Progress in Neurobiology, 2023 - Elsevier
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …