Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …

Glial cells are abundant in the CNS and are essential for brain development and
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …

Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are
associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque …

Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …

Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …