Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

CIN85 and CMS belong to a family of ubiquitously expressed adaptor molecules containing
three SH3 domains, a proline-rich region and a coiled-coil domain. By binding to numerous …

purpose. Oxidative injury to the retinal pigment epithelium (RPE) has been proposed to be
an important injury stimulus relevant to the accumulation of subretinal deposits in age …

Recent studies have led to the identification of a group of genes required for normal
biogenesis of lysosome-related organelles such as melanosomes and platelet-dense …

Age-related macular degeneration (AMD) represents the leading cause of vision loss in the
elderly. Accumulation of lipid-and protein-rich deposits under the retinal pigment epithelium …

Altering the number of surface receptors can rapidly modulate cellular responses to
extracellular signals. Some receptors, like the transferrin receptor (TfR), are constitutively …

FM1-43, a fluorescent styryl dye that penetrates into and stains membranes, was used to
investigate kinetics of constitutive endocytosis and to visualize the fate of endocytic …

Rho GTPases are key regulators of actin and microtubule dynamics and organization.
Increasing evidence shows that many viruses have evolved diverse interactions with Rho …

Exogenously and endogenously originated signals are propagated within the cell by
functional and physical networks of proteins, leading to numerous biological outcomes …

Early during de novo infection of human microvascular dermal endothelial (HMVEC-d) cells,
Kaposi's sarcoma-associated herpesvirus (KSHV)(human herpesvirus 8 [HHV-8]) induces …