Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Ketamine, an N-methyl-D-aspartate receptor antagonist, is widely known as a dissociative
anesthetic and phencyclidine derivative. Due to an undesirable adverse event profile when …

Age-and gender-matched reference values are essential for the clinical use of quantitative
sensory testing (QST). To extend the standard test sites for QST—according to the German …

Accumulating evidence indicates that purinergic P2X4 receptors (P2X4R: cation channels
activated by extracellular ATP) expressed in spinal microglia are crucial for pathological …

Introduction: The use of ketamine infusions for chronic pain has surged, with utilization
exceeding the proliferation of knowledge. A proposed mechanism for the long-term benefit …

Herpetic‐related neuralgia (HN) caused by varicella‐zoster virus (VZV) infection is one of
the most typical and common neuropathic pain in the clinic. However, the potential …

MATERIALS AND METHODS Animals Male C57BL/6 mice (Japan SLC, Ltd., Shizuoka,
Japan), 6 weeks of age at the start of experiments, were used. They were housed 4—6 per …

Background The aim of this study was to assess the preventative effect of ketamine on the
exaggerated postoperative pain observed in sufentanil-treated mice and its ability to …

In humans, proof of long-term efficacy of ketamine treatment in neuropathic pain is lacking.
To improve our understanding of ketamine behavior under various administration …

Central sensitization is one form of long-term plasticity in the central nervous system.
Sustained activation of primary sensory fibers supplying dorsal horn can induce long-lasting …