The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly
conserved parallel pathways. The well-studied co-translational pathway uses signal …

The biophysical rules that govern folding of small, single‐domain proteins in dilute solutions
are now quite well understood. The mechanisms underlying co‐translational folding of …

The first X-ray structure of the eukaryotic ribosome at 3.0 Å resolution was determined using
ribosomes isolated and crystallized from the yeast Saccharomyces cerevisiae (Ben-Shem A …

The ER Sec61 translocon is a large macromolecular machine responsible for partitioning
secretory and membrane polypeptides into the lumen, cytosol, and lipid bilayer. Because the …

Membrane proteins mediate a number of cellular functions and are associated with several
diseases and also play a crucial role in pathogenicity. Due to their importance in cellular …

The importance of peroxisomes is highlighted by severe inherited human disorders linked to
impaired peroxisomal biogenesis. Besides the simple architecture of these ubiquitous and …

The majority of cholesterol-dependent cytolysins (CDCs) utilize cholesterol as a membrane
receptor, whereas a small number are restricted to the GPI-anchored protein CD59 for initial …

The twin-arginine translocation (Tat) system that comprises the TatA, TatB, and TatC
components transports folded proteins across energized membranes of prokaryotes and …

The transport of proteins across the plasma membrane in bacteria requires a channel
formed from the SecY complex, which cooperates with either a translating ribosome in …