Captopril: an update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure

RN Brogden, PA Todd, EM Sorkin - Drugs, 1988 - Springer
Captopril is an orally active inhibitor of angiotensin-converting enzyme (ACE) and has been
widely studied in the treatment of patients with mild to moderate essential hypertension …

Haemodynamic responses to specific renin-angiotensin inhibitors in hypertension and congestive heart failure: a review

RJ Cody - Drugs, 1984 - Springer
The renin-angiotensin system is an important regulator of vascular resistance in many
patients with hypertension and congestive heart failure. To quantitatively evaluate this …

Naloxone reversal of hypotension due to captopril overdose

J Varon, SR Duncan - Annals of emergency medicine, 1991 - Elsevier
The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors
may be mediated by the endogenous opioid system. The opioid antagonist naloxone has …

Effect of captopril on skeletal muscle angiogenic growth factor responses to exercise

TP Gavin, DA Spector, H Wagner… - Journal of Applied …, 2000 - journals.physiology.org
Acute exercise increases vascular endothelial growth factor (VEGF), transforming growth
factor-β1 (TGF-β1), and basic fibroblast growth factor (bFGF) mRNA levels in skeletal …

The effect of perindopril and hydrochlorothiazide alone and in combination on blood pressure and on the renin-angiotensin system in hypertensive subjects

CL Brown, CI Backhouse, JC Grippat… - European journal of …, 1990 - Springer
The pharmacodynamic effects and acceptability of perindopril (4 mg daily) and
hydrochlorothiazide (25 mg daily) given alone or in combination for 1 month were …

The effect of captopril on the reflex control heart rate: possible mechanisms.

AA Ajayi, BC Campbell, PA Meredith… - British journal of …, 1985 - Wiley Online Library
Angiotensin converting enzyme inhibitors reduce blood pressure without reflex tachycardia,
possibly as a result of enhanced hypothesis that this results from the removal of the …

Angiotensin-converting enzyme inhibitors: relationship between pharmacodynamics and pharmacokinetics

GG Belz, W Kirch, CH Kleinbloesem - Clinical pharmacokinetics, 1988 - Springer
The inter-relationship between the pharmacokinetic and pharmacodynamic behaviour of
ACE inhibitors is reviewed. First, some of the methods which have been used to assess the …

The influence of captopril, the nitrates and propranolol on apparent liver blood flow.

AN Shepherd, PC Hayes, M Jacyna… - British journal of …, 1985 - Wiley Online Library
Indocyanine green estimated apparent liver blood flow was measured in normal volunteers
following glyceryl trinitrate, propranolol, isosorbide mononitrate and captopril. Glyceryl …

No sex-related pharmacokinetic and pharmacodynamic differences of captopril

E Massana, MJ Barbanoj, C Moros, A Morte… - Pharmacological …, 1997 - Elsevier
Captopril is an angiotensin-converting enzyme inhibitor (ACEI) used in the treatment of
hypertension and congestive heart failure and has demonstrated its cardiovascular effects in …

The influence of naloxone on the circulatory effects of captopril.

PC Rubin, JA Millar, S Sturani… - British journal of …, 1984 - Wiley Online Library
The fall in blood pressure produced by captopril is not accompanied by a compensatory
tachycardia. Angiotensin converting enzyme may participate in the metabolism of …