Helminth vaccines in ruminants: from development to application

E Claerebout, P Geldhof - Veterinary Clinics: Food Animal …, 2020 - vetfood.theclinics.com
The major helminth infections in ruminants include gastrointestinal (GI) nematodes, liver
fluke, and lungworms. At present, they are mainly controlled by regular treatments with …

Evaluation of efficacy expectations for novel and non-chemical helminth control strategies in ruminants

JK Ketzis, J Vercruysse, BE Stromberg, M Larsen… - Veterinary …, 2006 - Elsevier
The interest in novel methods of controlling helminth infections in ruminants is driven
primarily by the development of parasite resistance to currently available anthelmintics …

Plant-based production of a protective vaccine antigen against the bovine parasitic nematode Ostertagia ostertagi

L Zwanenburg, J Borloo, B Decorte, MJM Bunte… - Scientific Reports, 2023 - nature.com
The development of effective recombinant vaccines against parasitic nematodes has been
challenging and so far mostly unsuccessful. This has also been the case for Ostertagia …

Recombinant expression systems: the obstacle to helminth vaccines?

P Geldhof, V De Maere, J Vercruysse… - Trends in parasitology, 2007 - cell.com
The need for alternative ways to control helminth parasites has in recent years led to a boost
in vaccination experiments with recombinant antigens. Despite the use of different …

[PDF][PDF] Control of parasitic disease using vaccines: an answer to drug resistance?

J Vercruysse, TPM Schetters, DP Knox… - Revue Scientifique et …, 2007 - academia.edu
Antiparasitic drugs have been used successfully to control parasitic diseases in animals for
many years, as they are safe, cheap and effective against a broad spectrum of parasites …

Towards Delineating Functions within the Fasciola Secreted Cathepsin L Protease Family by Integrating In Vivo Based Sub-Proteomics and Phylogenetics

RM Morphew, HA Wright, EJ LaCourse… - PLoS neglected …, 2011 - journals.plos.org
Background Fasciola hepatica, along with Fasciola gigantica, is the causative agent of
fasciolosis, a foodborne zoonotic disease affecting grazing animals and humans worldwide …

Vaccination with an Ostertagia ostertagi Polyprotein Allergen Protects Calves against Homologous Challenge Infection

I Vercauteren, P Geldhof, J Vercruysse… - Infection and …, 2004 - Am Soc Microbiol
As an alternative to antihelminthic drugs, we are exploiting vaccination to control infections
with the abomasal nematode Ostertagia ostertagi in cattle. Our focus for vaccine targets is …

Cytokine responses in immunized and non‐immunized calves after Ostertagia ostertagi infection

E Claerebout, I Vercauteren, P Geldhof… - Parasite …, 2005 - Wiley Online Library
The objective of this study was to evaluate abomasal cytokine responses in helminth‐naive
calves and calves vaccinated with protective antigen fractions from Ostertagia ostertagi after …

Current research and future prospects in the development of vaccines against gastrointestinal nematodes in cattle

E Claerebout, DP Knox, J Vercruysse - Expert review of vaccines, 2003 - Taylor & Francis
Vaccination is being considered as the most feasible alternative for anthelmintic drugs to
control gastrointestinal nematode infections in cattle. However, despite the identification of …

Immune recognition of the surface associated antigen, Tc‐SAA‐1, from infective larvae of Teladorsagia circumcincta

AJ Nisbet, DP Knox, CM McNair, LI Meikle… - Parasite …, 2009 - Wiley Online Library
SUMMARY A cDNA encoding a surface‐associated antigen was amplified by reverse
transcriptase polymerase chain reaction (PCR) from RNA extracted from Teladorsagia …