Simple Summary Cancer is the second leading cause of death in the US. In 2023,
approximately 609,820 deaths from cancer are expected. Plexins are a family of receptors …

Cellular form and function are controlled by the assembly and stability of actin cytoskeletal
structures—but disassembling/pruning these structures is equally essential for the plasticity …

Actin-related protein 2/3 complex (Arp2/3 complex) catalyzes the nucleation of branched
actin filaments that push against membranes in processes like cellular motility and …

Aim The aim of this study was to clarify the significance of DNA methylation alterations of
cryptogenic hepatocellular carcinomas (HCCs). Methods Using the Infinium assay, we …

Metastasis promotes the development of tumors and is a significant cause of gastric cancer
death. For metastasis to proceed, tumor cells must become mobile by modulating their …

The actin cytoskeleton and reactive oxygen species (ROS) both play crucial roles in various
cellular processes. Previous research indicated a direct interaction between two key …

We analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60
cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin …

Mical family enzymes are unusual actin regulators that prime filaments (F-actin) for
disassembly via the site-specific oxidation of M44/M47. Filamentous actin acts as a substrate …

Mical1 regulates F-actin dynamics through the reversible oxidation of actin, a process
controlled by its interactions with various proteins. Upon binding to Rab8 family members …

Abstract MICAL (Molecule Interacting with CasL) proteins represent a unique family of actin
regulators crucial for synapse development, membrane trafficking, and cytokinesis. Unlike …