Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …

Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Antibodies are important therapeutic agents for cancer. Recently, it has become clear that
antibodies possess several clinically relevant mechanisms of action. Many clinically useful …

Chimaeric antigen receptor (CAR) T-cells are T-cells that have been genetically modified to
express an artificial construct consisting of a synthetic T-cell receptor (TCR) targeted to a …

The therapeutic utility of antibodies and their derivatives is achieved by various means. The
FDA has approved several targeted antibodies that disrupt signaling of various growth factor …

Immune T cells can kill cancer cells. Cancer vaccines function by increasing the number of
immune T cells. There are exceedingly strict biologic limits imposed on the immune system …

The primary function of myeloid cells is to protect the host from infections. However, during
cancer progression or states of chronic inflammation, these cells develop into myeloid …

Most therapeutic monoclonal antibodies (mAbs) licensed for human use or in clinical
development are indicated for treatment of patients with cancer and inflammatory …

Over the past decade, the clinical utility of monoclonal antibodies has been realized and
antibodies are now a mainstay for the treatment of cancer. Antibodies have the unique …