Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …

Asciminib is a potent, orally bioavailable, investigational drug that specifically and potently
inhibits the tyrosine kinase activity of native ABL1, together with that of the chimeric BCR …

The detailed understanding of the binding of small molecules to proteins is the key for the
development of novel drugs or to increase the acceptance of substrates by enzymes …

Macromolecular function frequently requires that proteins change conformation into high-
energy states,,–. However, methods for solving the structures of these functionally essential …

Src family kinases (SFKs) have a critical role in cell adhesion, invasion, proliferation,
survival, and angiogenesis during tumor development. SFKs comprise nine family members …

Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures
of protein kinase domains, both alone and in complexes, allows generalizations to be made …

Unregulated activation of Src kinases leads to aberrant signalling, uncontrolled growth and
differentiation of cancerous cells. Reaching a complete mechanistic understanding of large …

Although RAF kinases are critical for controlling cell growth, their mechanism of activation is
incompletely understood. Recently, dimerization was shown to be important for activation …

Src family protein kinases (SFKs) play a key role in cell adhesion, invasion, proliferation,
survival, apoptosis, and angiogenesis during tumor development. In humans, SFKs consists …

The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the
Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory …