PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …

Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality
worldwide. Endothelial dysfunction is a key player in the initiation and progression of …

The endothelium is the single-cell monolayer that lines the entire vasculature. The
endothelium has a barrier function to separate blood from organs and tissues but also has …

Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent
chronic inflammatory component that drives the atherosclerotic lesion progression in the …

Aging is a progressive degenerative process tightly integrated with inflammation. Cause and
effect are not clear. A number of theories have been developed that attempt to define the …

The secretion of cytokines by immune cells plays a significant role in determining the course
of an inflammatory response. The levels and timing of each cytokine released are critical for …

Abstract LOX‐1 (lectin‐like oxidized low‐density lipoprotein receptor‐1; also known as
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …

Medicinal plant‐derived bioactive compounds modulate multiple therapeutic targets in
cardiovascular diseases (CVDs), rendering herb‐derived phytochemicals effective against …