[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
Endothelial function and dysfunction: Impact of metformin
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality
worldwide. Endothelial dysfunction is a key player in the initiation and progression of …
worldwide. Endothelial dysfunction is a key player in the initiation and progression of …
Endothelial dysfunction and cardiovascular disease: History and analysis of the clinical utility of the relationship
The endothelium is the single-cell monolayer that lines the entire vasculature. The
endothelium has a barrier function to separate blood from organs and tissues but also has …
endothelium has a barrier function to separate blood from organs and tissues but also has …
Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function
X Han, WA Boisvert - Thrombosis and haemostasis, 2015 - thieme-connect.com
Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent
chronic inflammatory component that drives the atherosclerotic lesion progression in the …
chronic inflammatory component that drives the atherosclerotic lesion progression in the …
[HTML][HTML] Inflammation in aging: cause, effect, or both?
NS Jenny - Discovery medicine, 2012 - discoverymedicine.com
Aging is a progressive degenerative process tightly integrated with inflammation. Cause and
effect are not clear. A number of theories have been developed that attempt to define the …
effect are not clear. A number of theories have been developed that attempt to define the …
Intracellular trafficking and secretion of inflammatory cytokines
The secretion of cytokines by immune cells plays a significant role in determining the course
of an inflammatory response. The levels and timing of each cytokine released are critical for …
of an inflammatory response. The levels and timing of each cytokine released are critical for …
Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives
Abstract LOX‐1 (lectin‐like oxidized low‐density lipoprotein receptor‐1; also known as
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …
Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine danshen
Medicinal plant‐derived bioactive compounds modulate multiple therapeutic targets in
cardiovascular diseases (CVDs), rendering herb‐derived phytochemicals effective against …
cardiovascular diseases (CVDs), rendering herb‐derived phytochemicals effective against …