We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

Three dimensional (3D) tumor spheroid models are becoming important biomedical tools for
both fundamental and applied cancer studies, but current models do not account for different …

Introduction Lung cancer is a disease whose prognosis has remained poor in the last
decades. Recent advances in the understanding of the molecular pathways behind this …

Vascular development is a complex process regulated by dynamic biological networks that
vary in topology and state across different tissues and developmental stages. Signals …

Systemic administration of antiangiogenic drugs that target components of the vascular
endothelial growth factor A (VEGF-A; VEGF) signal transduction pathway has become a …