Obesity management in adults: a review

A Elmaleh-Sachs, JL Schwartz, CT Bramante… - Jama, 2023 - jamanetwork.com
Importance Obesity affects approximately 42% of US adults and is associated with increased
rates of type 2 diabetes, hypertension, cardiovascular disease, sleep disorders …

Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases

J Gutiérrez-Cuevas, A Santos… - International Journal of …, 2021 - mdpi.com
Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …

Structural brain changes associated with overweight and obesity

E Gómez-Apo, A Mondragón-Maya… - Journal of …, 2021 - Wiley Online Library
Obesity is a global health problem with a broad set of comorbidities, such as malnutrition,
metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This …

Therapeutic potential of semaglutide, a newer GLP-1 receptor agonist, in abating obesity, non-alcoholic steatohepatitis and neurodegenerative diseases: A narrative …

MK Mahapatra, M Karuppasamy, BM Sahoo - Pharmaceutical Research, 2022 - Springer
Introduction Semaglutide, a peptidic GLP-1 receptor agonist, has been clinically approved
for treatment of type 2 diabetes mellitus and is available in subcutaneous and oral dosage …

Artificial intelligence and machine learning approaches using gene expression and variant data for personalized medicine

S Vadapalli, H Abdelhalim, S Zeeshan… - Briefings in …, 2022 - academic.oup.com
Precision medicine uses genetic, environmental and lifestyle factors to more accurately
diagnose and treat disease in specific groups of patients, and it is considered one of the …

Obesity and diabetes

C Boutari, A DeMarsilis, CS Mantzoros - Diabetes Research and Clinical …, 2023 - Elsevier
Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol

W Jiao, S Mi, Y Sang, Q Jin, B Chitrakar, X Wang… - Food Chemistry, 2022 - Elsevier
This study explored the anti-obesity effect of 6-shogaol and the underlying mechanisms by
using Network pharmacology for the prediction and verification of molecular targets and …

The role of AMPK signaling in brown adipose tissue activation

JI van der Vaart, MR Boon, RH Houtkooper - Cells, 2021 - mdpi.com
Obesity is becoming a pandemic, and its prevalence is still increasing. Considering that
obesity increases the risk of developing cardiometabolic diseases, research efforts are …

Adiponectin and leptin in the diagnosis and therapy of NAFLD

C Boutari, CS Mantzoros - Metabolism-Clinical and …, 2020 - metabolismjournal.com
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and the
most prevalent cause of abnormal liver enzymes in the western world [1]. It is defined as the …

Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections

KD Hulme, EC Noye, KR Short, LI Labzin - Frontiers in immunology, 2021 - frontiersin.org
Acute inflammation is a critical host defense response during viral infection. When
dysregulated, inflammation drives immunopathology and tissue damage. Excessive …