Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …

The role of tumor mutational burden (TMB) in shaping tumor immunity is a key question that
has not been addressable using genetically engineered mouse models (GEMMs) of lung …

Cancer cells display persistent underlying chromosomal instability, with individual tumour
types intriguingly exhibiting characteristic subsets of whole, and subchromosomal …

Large-scale chromosomal aberrations are prevalent in human cancer, but their function
remains poorly understood. We established chromosome-engineered hepatocellular …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Centrosomes are the primary microtubule organizer in eukaryotic cells. In addition to
shaping the intracellular microtubule network and the mitotic spindle, centrosomes are …

Aneuploidy—the karyotype state in which the number of chromosomes deviates from a
multiple of the haploid chromosome set—is common in cancer, where it is thought to …

Mistakes in chromosome segregation leading to aneuploidy are the primary cause of
miscarriages in humans. Excluding sex chromosomes, viable aneuploidies in humans …

Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …