In pathophysiology, reactive oxygen species control diverse cellular phenotypes by
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …

Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …

Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …

Cellular DNA is constantly chemically altered by exogenous and endogenous agents. As all
processes of life depend on the transmission of the genetic information, multiple biological …

Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises
at gene regulatory elements by epigenetic demethylation during transcriptional activation …

Tissue stem cells undergo premature senescence under stress, promoting age-related
diseases; however, the associated mechanisms remain unclear. Here, we report that in …

Exposure to environmental pollutants poses a great threat to human health. Oxidative stress
is one of the widely accepted toxicity mechanisms of pollutants, and oxidative stress …

DNA single-strand breaks (SSBs) are among the most common lesions in the genome,
arising spontaneously and as intermediates of many DNA transactions. Nevertheless, in …