Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

[HTML][HTML] Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …

[HTML][HTML] Molecular and biotechnological aspects of secondary metabolites in actinobacteria

R Salwan, V Sharma - Microbiological research, 2020 - Elsevier
The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …

[HTML][HTML] Advances in Genetic Engineering Technology and Its Application in the Industrial Fungus Aspergillus oryzae

FJ Jin, S Hu, BT Wang, L Jin - Frontiers in Microbiology, 2021 - frontiersin.org
The filamentous fungus Aspergillus oryzae is an important strain in the traditional
fermentation and food processing industries and is often used in the production of soy …

[HTML][HTML] Applications of CRISPR/Cas9 in the synthesis of secondary metabolites in filamentous fungi

C Jiang, G Lv, Y Tu, X Cheng, Y Duan… - Frontiers in …, 2021 - frontiersin.org
Filamentous fungi possess the capacity to produce a wide array of secondary metabolites
with diverse biological activities and structures, such as lovastatin and swainsonine. With the …

Engineering the biosynthesis of fungal nonribosomal peptides

L Zhang, C Wang, K Chen, W Zhong, Y Xu… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …

Recent advances in the identification of biosynthetic genes and gene clusters of the polyketide-derived pathways for anthraquinone biosynthesis and biotechnological …

NK Mund, E Čellárová - Biotechnology Advances, 2023 - Elsevier
Natural anthraquinones are represented by a large group of compounds. Some of them are
widespread across the kingdoms, especially in bacteria, fungi and plants, while the others …

[HTML][HTML] Aspergillus niger as a Secondary Metabolite Factory

R Yu, J Liu, Y Wang, H Wang, H Zhang - Frontiers in Chemistry, 2021 - frontiersin.org
Aspergillus niger, one of the most common and important fungal species, is ubiquitous in
various environments. A. niger isolates possess a large number of cryptic biosynthetic gene …

CRISPR-mediated activation of biosynthetic gene clusters for bioactive molecule discovery in filamentous fungi

I Roux, C Woodcraft, J Hu, R Wolters… - ACS synthetic …, 2020 - ACS Publications
Accessing the full biosynthetic potential encoded in the genomes of fungi is limited by the
low expression of most biosynthetic gene clusters (BGCs) under common laboratory culture …