Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
[HTML][HTML] Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus …
JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities
RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …
[HTML][HTML] Molecular and biotechnological aspects of secondary metabolites in actinobacteria
R Salwan, V Sharma - Microbiological research, 2020 - Elsevier
The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …
agricultural and biotechnological applications make actinobacteria one of the most explored …
[HTML][HTML] Advances in Genetic Engineering Technology and Its Application in the Industrial Fungus Aspergillus oryzae
FJ Jin, S Hu, BT Wang, L Jin - Frontiers in Microbiology, 2021 - frontiersin.org
The filamentous fungus Aspergillus oryzae is an important strain in the traditional
fermentation and food processing industries and is often used in the production of soy …
fermentation and food processing industries and is often used in the production of soy …
[HTML][HTML] Applications of CRISPR/Cas9 in the synthesis of secondary metabolites in filamentous fungi
C Jiang, G Lv, Y Tu, X Cheng, Y Duan… - Frontiers in …, 2021 - frontiersin.org
Filamentous fungi possess the capacity to produce a wide array of secondary metabolites
with diverse biological activities and structures, such as lovastatin and swainsonine. With the …
with diverse biological activities and structures, such as lovastatin and swainsonine. With the …
Engineering the biosynthesis of fungal nonribosomal peptides
Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
Recent advances in the identification of biosynthetic genes and gene clusters of the polyketide-derived pathways for anthraquinone biosynthesis and biotechnological …
NK Mund, E Čellárová - Biotechnology Advances, 2023 - Elsevier
Natural anthraquinones are represented by a large group of compounds. Some of them are
widespread across the kingdoms, especially in bacteria, fungi and plants, while the others …
widespread across the kingdoms, especially in bacteria, fungi and plants, while the others …
[HTML][HTML] Aspergillus niger as a Secondary Metabolite Factory
R Yu, J Liu, Y Wang, H Wang, H Zhang - Frontiers in Chemistry, 2021 - frontiersin.org
Aspergillus niger, one of the most common and important fungal species, is ubiquitous in
various environments. A. niger isolates possess a large number of cryptic biosynthetic gene …
various environments. A. niger isolates possess a large number of cryptic biosynthetic gene …
CRISPR-mediated activation of biosynthetic gene clusters for bioactive molecule discovery in filamentous fungi
Accessing the full biosynthetic potential encoded in the genomes of fungi is limited by the
low expression of most biosynthetic gene clusters (BGCs) under common laboratory culture …
low expression of most biosynthetic gene clusters (BGCs) under common laboratory culture …