The spatial organization of transcriptional control
A Hafner, A Boettiger - Nature Reviews Genetics, 2023 - nature.com
In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …
transcription start site of genes, but are frequently thousands to millions of base pairs distal …
The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …
Genome organization controls transcriptional dynamics during development
Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …
of gene activity. Here, we show through high-resolution chromosome conformation analysis …
Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Liquid–liquid phase separation in chromatin
K Rippe - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
Chromosome-level organization of the regulatory genome in the Drosophila nervous system
Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …
genome organization. We present evidence of a previously unreported level of genome …
[HTML][HTML] Merging established mechanisms with new insights: condensates, hubs, and the regulation of RNA polymerase II transcription
M Palacio, DJ Taatjes - Journal of Molecular Biology, 2022 - Elsevier
The regulation of RNA polymerase II (pol II) transcription requires a complex and context-
specific array of proteins and protein complexes, as well as nucleic acids and metabolites …
specific array of proteins and protein complexes, as well as nucleic acids and metabolites …
The 3D architecture of the pepper genome and its relationship to function and evolution
The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …
genomes, though how and why they form varies considerably. Here we report a …
Essential role of Cp190 in physical and regulatory boundary formation
A Kaushal, J Dorier, B Wang, G Mohana… - Science …, 2022 - science.org
Boundaries in animal genomes delimit contact domains with enhanced internal contact
frequencies and have debated functions in limiting regulatory cross-talk between domains …
frequencies and have debated functions in limiting regulatory cross-talk between domains …