The spatial organization of transcriptional control

A Hafner, A Boettiger - Nature Reviews Genetics, 2023 - nature.com
In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

The molecular basis of heterochromatin assembly and epigenetic inheritance

SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Genome organization controls transcriptional dynamics during development

PJ Batut, XY Bing, Z Sisco, J Raimundo, M Levo… - Science, 2022 - science.org
Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …

Genome control by SMC complexes

C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Liquid–liquid phase separation in chromatin

K Rippe - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Chromosome-level organization of the regulatory genome in the Drosophila nervous system

G Mohana, J Dorier, X Li, M Mouginot, RC Smith… - Cell, 2023 - cell.com
Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …

[HTML][HTML] Merging established mechanisms with new insights: condensates, hubs, and the regulation of RNA polymerase II transcription

M Palacio, DJ Taatjes - Journal of Molecular Biology, 2022 - Elsevier
The regulation of RNA polymerase II (pol II) transcription requires a complex and context-
specific array of proteins and protein complexes, as well as nucleic acids and metabolites …

The 3D architecture of the pepper genome and its relationship to function and evolution

Y Liao, J Wang, Z Zhu, Y Liu, J Chen, Y Zhou… - Nature …, 2022 - nature.com
The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …

[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Essential role of Cp190 in physical and regulatory boundary formation

A Kaushal, J Dorier, B Wang, G Mohana… - Science …, 2022 - science.org
Boundaries in animal genomes delimit contact domains with enhanced internal contact
frequencies and have debated functions in limiting regulatory cross-talk between domains …