Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

This review of the current literature aims to study correlations between the chemical structure
and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of …

Abstract Poly (ADP-ribose) ylation (PARylation) by PAR polymerase 1 (PARP1) and
PARylation removal by poly (ADP-ribose) glycohydrolase (PARG) critically regulate DNA …

Tannins are soluble, astringent secondary phenolic metabolites generally obtained from
renewable natural resources, and can be found in many plant parts, such as fruits, stems …

Human cells respond to DNA damage with an acute and transient burst in production of poly
(ADP-ribose), a posttranslational modification that expedites damage repair and plays a …

Tannins dominate quantitatively the vast plant secondary metabolites, being the fourth most
abundant compounds in the plant vascular tissue next to cellulose, hemicelluloses, and …

Abstract Poly (ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the
hydrolysis of poly (ADP-ribose)(PAR), an essential biopolymer that is synthesized by poly …

Herpes simplex virus 1 infection triggers multiple changes in the metabolism of host cells,
including a dramatic decrease in the levels of NAD+. In addition to its role as a cofactor in …

An excessive activation of poly (ADP-ribose) polymerases (PARPs) may trigger a form of
neuronal death similar to that occurring in neurodegenerative disorders. To investigate this …

Macrodomains are evolutionarily conserved structural elements. Many macrodomains
feature as binding modules of ADP-ribose, thus participating in the recognition and removal …