G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering
intracellular signaling through coupling with G proteins and arrestins. Recent breakthroughs …

Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the
information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the …

Dystonia is a clinically and genetically highly heterogeneous neurological disorder
characterized by abnormal movements and postures caused by involuntary sustained or …

Nutrient sensing is a mechanism for organisms to sense their environment. In larger
animals, including humans, the intestinal tract is a major site of nutrient sensing for the body …

G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to
their druggability, diversity and physiological efficacy. Many drugs selectively target specific …

G protein coupled receptors have historically been one of the most druggable classes of
cellular proteins. The members of this large receptor gene family couple to primary effectors …

G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human
physiology in response to a wide array of different extracellular stimuli and thus represent …

Chemogenetic technologies enable selective pharmacological control of specific cell
populations. An increasing number of approaches have been developed that modulate …

G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

Seven transmembrane G protein-coupled receptors (GPCRs) are often phosphorylated at
the C terminus and on intracellular loops in response to various extracellular stimuli …