Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only
affects acute morbidity and mortality, but also a patient's long-term prognosis. In this …

Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Purpose Voriconazole, an antifungal drug, is metabolized by a cytochrome P450 isozyme.
Increased adverse effects are observed in Asians because of the high rate of poor …

Area under the concentration–time curve (AUC)-guided vancomycin treatment is associated
with decreased nephrotoxicity. It is preferable to obtain two samples to estimate the AUC …

Background Owing to its low risk of adverse effects, teicoplanin has been extensively used
in patients with infections caused by MRSA. To promote the better management of patients …

Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is
known to improve patient outcomes compared with fixed or empirical dosing strategies …

This systematic review and meta-analysis compares the efficacy of daptomycin and
vancomycin in adult patients with bacteremia by methicillin-resistant Staphylococcus aureus …

Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has
become a major global and public health concern not only in terms of morbidity and mortality …

Introduction Consensus guidelines recommend targeting a vancomycin area under the
curve to minimum inhibitory concentration (AUC24: MIC) ratio of 400–600 to improve …

Although vancomycin (VCM)—frequently used to treat drug-resistant bacterial infections—
often induces acute kidney injury (AKI), discontinuation of the drug is the only effective …